U-47700 is an opioid analgesic drug developed by a team at Upjohn in the 1970sthat has around 7.5 x the potency of morphine in animal models.
U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activityand posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.
CAS Number
• 82657-23-6
PubChem CID
• 13544016
ChemSpider
• 23113403
UNII
• 6IY4WX208T
ChEMBL
• CHEMBL277572
Chemical and physical data
Formula
C16H22Cl2N2O
Molar mass
329.27 g•mol−1
U-47700 is a structural isomer of the earlier opioid AH-7921 and the result of a great deal of work elucidating the quantitative structure–activity relationship of the scaffold. Upjohn looked for the key moieties which gave the greatest activityand posted over a dozen patents on related compounds, each optimizing one moiety until they discovered that U-47700 was the most active.
CAS Number
• 82657-23-6
PubChem CID
• 13544016
ChemSpider
• 23113403
UNII
• 6IY4WX208T
ChEMBL
• CHEMBL277572
Chemical and physical data
Formula
C16H22Cl2N2O
Molar mass
329.27 g•mol−1
Main Products
apvp